GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs7615952 | 1 | rs7616044 | chr3:125649354 | LOC100125556 | chr3:125635444-125648865:+ | 0.72 | 5.75 | 1.07E-7 | Blood pressure (smoking interaction) |
| THYM | cis | rs9815354 | 1 | rs7616844 | chr3:41874343 | ULK4 | chr3:41288091-42003660:- | 1.02 | 11.47 | 1.22E-19 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs7617397 | chr3:41959037 | ULK4 | chr3:41288091-42003660:- | -1.02 | -11.59 | 6.88E-20 | Diastolic blood pressure |
| THYM | cis | rs10935120 | 1 | rs7619451 | chr3:134233238 | ANAPC13 | chr3:134196547-134204865:- | 0.51 | 5.2 | 1.16E-6 | Height |
| THYM | cis | rs1401999 | 1 | rs7620350 | chr3:183710053 | ABCC5 | chr3:183637726-183735727:- | 0.48 | 4.28 | 4.53E-5 | Anterior chamber depth |
| THYM | cis | rs9815354 | 1 | rs7622259 | chr3:41881351 | ULK4 | chr3:41288091-42003660:- | 1.02 | 11.47 | 1.22E-19 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs7624372 | chr3:41881107 | ULK4 | chr3:41288091-42003660:- | 1.02 | 11.47 | 1.22E-19 | Diastolic blood pressure |
| THYM | cis | rs9876781 | 1 | rs7630741 | chr3:48419723 | TREX1 | chr3:48501186-48509043:+ | -0.28 | -4.25 | 5.0E-5 | Longevity |
| THYM | cis | rs10935120 | 1 | rs7630874 | chr3:134293291 | ANAPC13 | chr3:134196547-134204865:- | -0.59 | -8.13 | 1.58E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs7630874 | chr3:134293291 | CEP63 | chr3:134204575-134293852:+ | -0.41 | -5.87 | 6.33E-8 | Height |
| THYM | cis | rs9815354 | 1 | rs7631057 | chr3:41817951 | ULK4 | chr3:41288091-42003660:- | 0.96 | 10.26 | 4.69E-17 | Diastolic blood pressure |
| THYM | cis | rs9815354 | 1 | rs7632387 | chr3:41853161 | ULK4 | chr3:41288091-42003660:- | 0.94 | 9.62 | 1.09E-15 | Diastolic blood pressure |
| THYM | cis | rs9876781 | 1 | rs7634377 | chr3:48421258 | TREX1 | chr3:48501186-48509043:+ | -0.28 | -4.25 | 5.0E-5 | Longevity |
| THYM | cis | rs9876781 | 1 | rs7635522 | chr3:48423656 | TREX1 | chr3:48501186-48509043:+ | -0.28 | -4.36 | 3.35E-5 | Longevity |
| THYM | cis | rs9876781 | 1 | rs7636044 | chr3:48484560 | TREX1 | chr3:48501186-48509043:+ | -0.29 | -4.28 | 4.47E-5 | Longevity |